Three dominant themes in the discussion
| Theme | Supporting quotations |
|---|---|
| 1. Public awareness of repurposing studies | “You can also search here: https://clinicaltrials.gov/” – astura “Communities (on‑line or off‑line) of people who share your disorder, and maybe health care professionals who see many patients with your disorder.” – bell‑cot |
| 2. Off‑label prescribing is common and often reimbursed | “Off label prescribing is extremely common.” – Aurornis “Insurance absolutely covers off label use. And depending on the area of medicine, off label use can be incredibly common (see cardiac pediatrics).” – jpk2f2 “That’s a lie, I get off‑label drugs prescribed monthly covered.” – tekla |
| 3. Patent expiry and regulatory hurdles block formal repurposing and commercial exploitation | “There is no regulatory pathway to extend the use of existing drugs for new indications of use without the consent of the manufacturer (or becoming a manufacturer yourself).” – oezi “The patents aren’t hindering off‑label use. The hinder commercial exploitation by others.” – oezi “The article points out that it is typically after patent expiry that the universities and hospitals start looking at repurposing.” – vidarh |